what we do
Novel Regulators of Cell Mechanotransduction
The quiet influence of Thy-1
Thy-1, and perhaps numerous GPI-linked, integrin binding membrane proteins, have tremendous potential to alter how cells sense and respond to their mechanical environment.
Hijacking the Cell's Mechanotransduction Machinery
Finding the leverage point
A host of intracellular signaling molecules and transcription factors help realize the cell's intended responses to the mechanical microenvironment.
Hey, don't forget the Matrix
Fibronectin is our hyper-elastic friend
Fibronectin and many other ECM proteins exhibit significant molecular deformation under force. Do these deformations drive meaningful altered interactions with cells?
Time is not on our side
The incongruity between acute mechanotransduction and chronic disease progression
How mechanotransduction within cells and the matrix drive lasting changes in tissue remodeling are incompletely understood.
the motley crew
Countless hours, poor pay, and an absent-minded Principal Investigator all qualify these guys as heroes & lab rats!
Anton is developing new protein expression systems for therapeutic antibody production and protein evolution.
Vincent's research focuses on endogenous heterogeneity in fibroblast mechanotransduction.
Michelle is exploring thermodynamic principles of motility using synthetic particle systems.
Wei's research is focused on fibronectin mechanics and deformation under force.
Ping is focused on further exploring Thy-1's role in directing integrin signaling and mechanotransduction.
NIH MD/PhD Predoctoral Fellow, 4th Year
Dwight is developing novel gene-based therapies that leverage cell mechanotransduction.
NSF and NIH Predoctoral Fellow, 4th Year
Vicky's research is focused on how post-translational modifications to the provisional (wound healing) ECM alter fibroblast phenotype.
GAANN Predoctoral Fellow,
Haylee is working on a therapeutic antibody that blocks specific cell-ECM interactions and we believe could inhibit myofibroblast differentiation.
NSF Predoctoral Fellow,
John is now working on the development of unique platelet-like particles for hemostasis and endeavors to get us to Phase I clinical trials!
1st Year PhD Student
Leandro is still figuring out where the light switches are, but is working toward learning directed evolution and antibody engineering.
Dr. Sarah Stabenfeldt - Assistant Professor, Arizona State Univ.
Dr. Ashley Brown - Assistant Professor @ NC State Univ.
Dr. Allyson Soon - Research Scientist @ Nanyang Technical Univ.
Dr. Rodney Averett - Assistant Professor, Univ. of Georgia
Dr. Kelly Clause - destination unknown
Dr. Lizhi Cao - Postdoc Fellow,
Dr. Marilyn Markowski - Postdoc Biomed Engr, Halyard Health
Dr. Vincent Fiore - Postdoc Fellow, Elaine Fuchs Lab, Rockefeller
Dr. Alison Douglas - Research Scientist, Suneris
We're all just trying to find happiness
The folks in my lab remind me that we are each on a journey. Sometimes we have detours and sometimes we find ourselves unintentionally in the fast lane. They help me on my journey every day and I hope, in return, I help them find their way too.
My own "regenerative medicine" experiment
The small band of humans that tolerate me
Thankfully a handfull of individuals put up with me and for that I'm very grateful. These folks share a common love for food, travel, and family
Yeah, major driver in my life
I have a healthy love for cooking and eating. I like to cook and eat just about anywhere I am. Eating is good and I particularly like eating at places that take you someplace you've never been before.
National Institutes of Health
2 Postdoc & Fellow-to-Faculty Fellowships
5 Predoctoral MD/PhD & PhD Fellows & Trainees
American Heart Association
2 Postdoc & Predoctoral Fellows